Genistein CAS NO.446-72-0

Name Genistein Ingredient Genistein Specification 98% Test method HPLC genistein Herb Source Genista tinctoria Linn. Sophora su…

Name Genistein Ingredient Genistein Specification 98% Test method HPLC genistein Herb Source Genista tinctoria Linn. Sophora subprostrata Chun et T. Chen Trifolium pratense Linn. genistein Molecular Formula and Molecular Weight C15H10O5；270.25 genistein Melting Point 297℃-298℃ genistein Solubility Soluble in DMSO and ethanol，Practically insol in water genistein Pharmacology Genistein belongs to the isoflavone class of flavonoids. It is also classified as a phytoestrogen. Phytoestrogens are plant-derived nonsteroidal compounds that possess estrogen-like biological activity. Genistein has been found to have both weak estrogenic and weak anti-estrogenic effects. Genistein is the aglycone (aglucon) of genistin. The isoflavone is found naturally as the glycoside genistin and as the glycosides 6"-O-malonylgenistin and 6"-O-acetylgenistin. Genistein and its glycosides are mainly found in legumes, such as soybeans and chickpeas. Soybeans and soy foods are the major dietary sources of these substances. Nonfermented soy foods, such as tofu, contain higher levels of the genistein glycosides, while fermented soy foods, such as tempeh and miso, contain higher levels of the aglycone. Genistein has weak estrogenic activity as measured in in vivo and in vitro assays. In vivo, its estrogenic activity is one-third that of glycitein and four times greater than that of daidzein. Genistein has been found to have a number of antioxidant activities. It is a scavenger of reactive oxygen species and inhibits lipid peroxidation. It also inhibits superoxide anion generation by the enzyme xanthine oxidase. In addition, genistein, in animal experiments, has been found to increase the activities of the antioxidant enzymes superoxide dismutase, glutathione peroxidase, catalase and glutathione reductase.